The risk is always there for your CPU to be crushed under the pressure, even when you don't even touch it. Albeit less imperative when the clip is not stronger than Arnold Schwarzenegger (ahem, Globalwin), but the risk is always there.
If you have an extremely careful set of hands, then you've really got nothing to worry about. Just make sure that it is cooled down pretty well after shutting the computer down before removing the heatsink. Cracking damage from heat expansion can occur if the CPU is, e.g., about 60 degrees and you just pop off the heatsink right after you shut it off (As I experienced with one of my CPUs)
Even if you do have a careful hand, I would highly recommend getting a spacer to prevent crushing your CPU.
The OCZ store sells a
copper spacer. It doesn't assist cooling in any way other than helping it not to crush your CPU. I use one on my T-bird (with their excellent
Glacier 2, which is down to $7 USD) and it's currently happily
crunching away in
Genome@home for the
OCN Hellspawns without any (literal) crunching problems.
Good luck